Archive | Extra-nuclear Initiated Estrogen Receptor Signaling

RSS feed for this section

Genomic Collaboration of Estrogen Receptor alpha (ERα) and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs, Madak-Erdogan Z, Lupien M, Stossi F., Brown M, Katzenellenbogen BS, Molecular and Cellular Biology. 2011, Jan;31(1):226-36

The nuclear hormone receptor, estrogen receptor α (ERα), and mitogen-activated protein kinases (MAPKs) play key roles in hormone-dependent cancers, and yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interacts with extracellular signal-regulated kinase 2 (ERK2), a downstream effector in the […]

Read full story Comments are closed

Non-nuclear Estrogen Receptor α Signaling Promotes Cardiovascular Protection but not Uterine or Breast Cancer Growth in Mice,Chambliss K.L, Wu Q., Oltmann S, Umetani M, Korach K.L., Thomas G.D., Mineo C., Yuhanna I.S., Kim S.H., Madak-Erdogan Z., Maggi A., Dineen S.P., Roland C.L., Brekken R.A., Katzenellenbogen J.A., Katzenellenbogen B.S., Shaul P.W., Journal of Clinical Investigation, 2010,120(7):2319:2330

Steroid hormone receptors function classically in the nucleus as transcription factors. However, recent data indicate that there are also non-nuclear subpopulations of steroid hormone receptors, including estrogen receptors (ERs), that mediate membrane-initiated signaling of unclear basis and significance. Here we have shown that an estrogen-dendrimer conjugate (EDC) that is excluded from the nucleus stimulates endothelial […]

Read full story Comments are closed

Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors, Madak-Erdogan Z, Kieser KJ, Kim SH, Komm B, Katzenellenbogen JA, Katzenellenbogen BS,Molecular Endocrinology. 2008; 22 (9): 2116-2127

Whereas estrogens exert their effects by binding to nuclear estrogen receptors (ERs) and directly altering target gene transcription, they can also initiate extranuclear signaling through activation of kinase cascades. We have investigated the impact of estrogen-mediated extranuclear-initiated pathways on global gene expression by using estrogen-dendrimer conjugates (EDCs), which because of their charge and size remain […]

Read full story Comments are closed

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action, Harrington WR, Kim SH, Funk CC, Madak-Erdogan Z, Schiff R, Katzenellenbogen JA, Katzenellenbogen BS, Molecular Endocrinology. 2006; 20(3):491-502.

Estrogenic hormones are classically thought to exert their effects by binding to nuclear estrogen receptors and altering target gene transcription, but estrogens can also have nongenomic effects through rapid activation of membrane-initiated kinase cascades. The development of ligands that selectively activate only the nongenomic pathways would provide useful tools to investigate the significance of these […]

Read full story Comments are closed